Uridine monophosphate (UMP) CAS NO.58-97-9

Uridine monophosphate  (UMP)

Chemical name 5'-uridylic acid 

Cas 58-97-9

Molecular formula  C9H13N2O9P

Molecular weight  324.181

Abstract Uridine monophosphate, also known as 5'-uridylic acid and abbreviated UMP, is a nucleotide that is used as amonomer in RNA. It is an ester of phosphoric acid with the nucleoside uridine. UMP consists of the phosphate group, thepentose sugar ribose, and the nucleobase uracil; hence, it is a ribonucleoside monophosphate. Another common shorthand for the molecule is uridylate - the deprotonated form of the molecule, which is predominant in aqueous solution. As asubstituent it takes the form of the prefix uridylyl-. The deoxy form is abbreviated dUMP.

Biosynthesis

Uridine monophosphate is formed from Orotidine 5'-monophosphate (orotidylic acid) in a decarboxylation reaction catalyzed by the enzyme orotidylate decarboxylase. Uncatalyzed, the decarboxylation reaction is extremely slow (estimated to occur on average one time per 78 million years). Adequately catalyzed, the reaction takes place once per second, an increase of 1017-fold.[2]

In humans, the orotidylate decarboxylase function is carried out by the protein UMP synthase.[3] Defective UMP synthase can result in orotic aciduria, a metabolic disorder.

Uridine monophosphate  (UMP)

Chemical name 5'-uridylic acid 

Cas 58-97-9

Molecular formula  C9H13N2O9P

Molecular weight  324.181

Abstract Uridine monophosphate, also known as 5'-uridylic acid and abbreviated UMP, is a nucleotide that is used as amonomer in RNA. It is an ester of phosphoric acid with the nucleoside uridine. UMP consists of the phosphate group, thepentose sugar ribose, and the nucleobase uracil; hence, it is a ribonucleoside monophosphate. Another common shorthand for the molecule is uridylate - the deprotonated form of the molecule, which is predominant in aqueous solution. As asubstituent it takes the form of the prefix uridylyl-. The deoxy form is abbreviated dUMP.

Biosynthesis

Uridine monophosphate is formed from Orotidine 5'-monophosphate (orotidylic acid) in a decarboxylation reaction catalyzed by the enzyme orotidylate decarboxylase. Uncatalyzed, the decarboxylation reaction is extremely slow (estimated to occur on average one time per 78 million years). Adequately catalyzed, the reaction takes place once per second, an increase of 1017-fold.[2]

In humans, the orotidylate decarboxylase function is carried out by the protein UMP synthase.[3] Defective UMP synthase can result in orotic aciduria, a metabolic disorder.